August 21, 2025

Why Your Antidepressants Aren’t Working (And What to Do Instead) w/ Everest Goldstein

Why Your Antidepressants Aren’t Working (And What to Do Instead) w/ Everest Goldstein

When people come into the pharmacy with mood issues like anxiety and depression, they are surprised to hear that there might be a physiological root cause.

Traditional medicine doesn’t bother to dig into that. Most people are prescribed SSRIs and told they have drug-resistant depression when they don’t work.

But what if those symptoms are actually signals from the rest of your body begging you to look deeper?

That’s where functional psychiatry comes in.

Board-certified psychiatric nurse practitioner and certified functional medicine provider, Everest Goldstein has built a career doing exactly that.

When it comes to mental health, Everest doesn’t see depression or anxiety as fixed “diagnoses” to medicate indefinitely; she sees them as symptoms pointing to deeper imbalances.

In this episode, Everest shares the unfiltered truth about why conventional psychiatry misses the mark and the lab tests and functional tools that actually uncover what’s wrong. She also shares the under-the-radar compounds and supplements that can completely change the trajectory of your mental health.

 

Things You’ll Learn In This Episode 

-Beyond the chemical imbalance myth
“Low serotonin” isn’t the full story. How does conventional psychiatry’s diagnostic playbook miss the root causes of depression and anxiety?

-Menopause, mood, and misdiagnosis
How do hormonal shifts in perimenopause and menopause trigger anxiety, insomnia, and irritability? Do antidepressants often make things worse?

-Psychobiotics and the gut-brain axis
The gut and brain might be far away from each other, but they are very connected. What probiotic strains directly influence mood, anxiety, and cognition? 

-Functional compounds you’ve never heard of
From methylene blue to low-dose naltrexone to lithium orotate, how do these overlooked tools reduce brain inflammation and help patients finally respond to treatment?